Pernicious Anemia
Low red blood cell content. Digestive and nervous disorders. Affection of the gastric parietal cells.
Manifested by asthenia, pallor, palpitations, hypotension.
Variety of anemia that can occur after the 4th month of pregnancy (pregnant anemia) or during the first two years of life (juvenile anemia).
Progressive pernicious anemia, also called Biermer, Addison's anemia, megalocytic hyperchromic anemia, idiopathic anemia, is characterized by a considerable decrease in the number of red blood cells, their increase in volume and their greater hemoglobin content. It affects approximately 4% of the population.
It presents as an autoimmune atrophic gastritis which causes a deficiency of vitamin B12 through malabsorption. It is accompanied by digestive disorders (Hunter's glossitis, atrophy of the digestive mucous membranes) and nervous disorders (neuroanemic syndrome). Low stomach acid predisposes to vitamin B12 deficiency, especially in older people. Certain intestinal diseases (e.g. Crohn's, ulcerative colitis, celiac) are among the well-known causes of pernicious anemia.
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